Title of publication
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Summary of findings
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Citation
(* free on the net)
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Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy.
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The review updates vitamin D and K skeletal and cardiovascular benefits and evidence for their synergy of action.
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*Kidd PM, Altern Med Rev. 2010, 15:199-222.
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Vitamin K: The coagulation vitamin that became omnipotent
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Authors raise the question if many healthy individuals are sub-clinical vitamin K-deficient based the fact that fractions of osteocalcin and MGP are circulating as incompletely carboxylated species. They suggest vitamin K use in dietary supplements and functional foods for healthy individuals to prevent bone and vascular disease.
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Cranenburg ECM, Schurgers LJ, Vermeer C, Thromb Haemost. 2007,;98:120-5.
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Cardiovascular disease and bone. Review.
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The authors points to strong evidence that osteoporosis-related fractures and coronary artery disease, stroke and peripheral artery disease are associated. There are common pathways in the pathophysiology of these two conditions that can explain the link.
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Eastell R, Newman C and Crossman DC. Arch Biochem Biophys. 2010 Nov 1;503(1):78-83
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Association of osteocalcin and abdominal aortic calcification in older women: the study of osteoporotic fractures
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The present study included a subsample of 363 randomly selected women (age 65 year or above) from The Study of Osteoporotic Fractures (SOF).
There was no observed association of osteocalcin and abdominal aortic calcification (AAC) in either unadjusted or adjusted analyses.
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*Parker BD, Bauer DC, Ensrud KE, et al. Calcif Tissue Int. 2010 Mar;86(3):185-91
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Roles of vitamin K beyond. Review
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Role of vitamin K in bone, in vascular calcification and inflammation.
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Booth SL, Annu Rev Nutr. 2009;29:89-110
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Low bone mineral density is related to echogenic carotid artery plaques: a population-based study.
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In a 1994–1995 cross-sectional, population-based study of 2,543 men and 2,726 postmenopausal women aged 55–74 years in Tromsø, Norway; the authors assessed a possible relation between bone mineral density (BMD) and the prevalence of carotid artery plaques, with an emphasis on plaque morphology. This study indicates that low bone mass is associated with an increased risk of echogenic calcified atherosclerotic plaques but not with a risk of echolucent plaques.
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*Jørgensen L, Joakimsen O, Rosvold Berntsen GK, et al. Am J Epidemiol. 2004 Sep 15;160(6):549-56
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Osteoporosis and atherosclerosis: biological linkages and the emergence of dual-purpose therapies. Review
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This paper discusses the relation
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