Kappa Bioscience
Daily Dosage & Overage

Daily Dosage & Overage

Recommended daily dosage

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Daily Dosage & Overage

See what CEO Egil Greve from Kappa Bioscience has to say about K2.

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How do you calculate the overdose amount for K2? 

Light and shelf-life are the two key factors that in uence vitamin K2 overdose.

Calculations are:


The overdose amount must compensate for the decomposition of vitamin K2 caused by the direct influence of light during the production process. Assuming 1- 3 hours of light during production and processing, we recommend the following overdose.

Shelf life:

The overdose amount must also compensate for the decomposition of vitamin K2 during its minimum shelf. K2VITAL® products normally have a shelf life of 36 months from their date of manufacture. The precondition for this is proper packaging and storage of the product in closed containers, protected against light.

The shelf life and overdose amounts are different for mono-K2 and K2 preparations in combination.

The shelf life of mono- K2 preparations:

For mono-K2 preparations, with the carrier substances – microcrystalline cellulose (MCC) and/or medium chain triglyceride oil (MCT), no separate overdose is necessary for a 24-month finished product shelf life period. It must, in all cases, be ensured that the finished product is protected against light.

The shelf life of vitamin K2 preparations in combination:

K2 in combination with other ingredients can provide superior health benefits. For example, in the field of bone health, staple ingredients include calcium, magnesium, vitamin D3, collagen peptides, zinc and vitamin C. For cardiovascular health, frequent co-ingredients include magnesium, phytosterine, L-arginine, B vitamins, omega-3 concentrates made of fish and krill oil, and a range of medicinal plants. Unfortunately, the stability of vitamin K2 in combination with minerals, herbal extracts, animal or vegetable raw materials, amino acids, and other nutrients is more problematic, compared to mono-K2 preparations. Hence, the stable, microencapsulated K2VITAL® DELTA is the ideal choice for vitamin K2 preparations in combination. The Table below lists the overdose recommendations for fermentationderived K2 and K2VITAL® DELTA when combined with co-ingredients such as calcium, magnesium or L-arginine (based on current information).

Overdose recommendations for fermentation-derived K2 and microencapsulated K2VITAL® DELTA when combined with other ingredients in formulation

  • Quality & Safety
  • Science Papers
  • Tutorial: Quality & Safety

Purity: all-trans vitamin K2 MK-7 (USP).
Quality: GMP, HACCP, ISO 22000:2005 manufacturing and distribution standards.
Stability: Patent-pending microencapsulation technology ensures stability in challenging formulations.
Long shelf life in finished products: 36 months shelf life on all ingredients; supported by extensive stability data on ingredients and finished formulations.
Approvals: Novel Food (EU), TGA (AUS), sGRAS (USA), drug registration in India (2017). Application processes are initiated in countries including China, Thailand and others. Kosher and Halal certifications.

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Daily Dosage & Overage

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