Kappa Bioscience
Introduction of K2

K2 Introduction

Vitamin K2 – one Vitamin for both bone and heart health


Introduction

See what CEO Egil Greve from Kappa Bioscience has to say about K2


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Vitamin K2 puts calcium where it is needed – into bones, not arteries

K2 bridges bone and heart health via its actions on calcium. Calcium is required to build and maintain healthy bones, but excess calcium deposited in arteries can lead to arterial stiffening - a leading cofactor in heart disease. With adequate vitamin K2 intake, calcium is directed towards the bone, and away from arteries. Vitamin K2 puts calcium in balance.


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Our diets do not provide us with enough vitamin K2

Vitamins are nutrients our body needs. They cannot be produced internally in sufficient quantities, so must be obtained through the diet. This includes vitamin K2. Fermented foods are primary sources of vitamin K2. Western diets are deficient in vitamin K2. As such, K2 must be supplemented for optimal bone and heart health. Research indicates that 90-120 μg of vitamin K2 as a daily dose is sufficient for good bone health. Populations that reach the recommended daily dose, such as Japanese people consuming natto (a dish high in K2), were shown to have lower rates of bone and heart disease.


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Vitamin K2 deficiency is common in Western populations

A deficiency in vitamin K2 may lead to calcium being deposited in arteries instead of bones, compromising both bone and heart health. The evidence is growing that all populations, from neonatal to geriatric, require vitamin K2 for optimal body function. The good news is that K2 deficiencies can be overcome by supplementation of K2VITAL®.


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The Bone Health Triangle® includes the tri-essentials for bone health: calcium, vitamins D3 and K2

Calcium is needed for building a strong bone matrix. Vitamin D3 aids the absorption of calcium into the blood, where it can be put to work. Vitamin K2 activates the proteins that integrate calcium into bone. Calcium and vitamin D3 alone, without vitamin K2, will not ensure the proper function of calcium for the maintenance of healthy bones. Since dietary intakes of vitamin K2 are generally low, all products containing calcium or D3 can benefit from formulation extensions that include K2VITAL®.


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Vitamin K2 prevents and reduces arterial calcification

Excess calcium deposited in arteries can lead to arterial stiffening - a leading co-factor in heart disease. Vitamin K2 activates matrix Gla protein (MGP) to prevent calcium deposit in the smooth muscle cells of the vascular system. Activated MGP binds excess calcium and removes it, reducing the risk of deposits in vessels and arteries. Studies have documented the beneficial effects of vitamin K2 supplementation for improving cardiovascular health.

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Scalable capacity for mass-market production demands: Kappa’s current production capacity already exceeds the total projected yearly global vitamin K2 demand through 2020.
Industry-leading pricing: Kappa continuously reinvests in R&D and manufacturing processes to drive ingredient price points to levels that support commercial adoption. In 2017, Kappa led the market with a 45% price reduction – marking a significant step on the path to mass-market commercialization of K2.

Purity: all-trans vitamin K2 MK-7 (USP).
Quality: GMP, HACCP, ISO 22000:2005 manufacturing and distribution standards.
Stability: Patent-pending microencapsulation technology ensures stability in challenging formulations.
Long shelf life in finished products: 36 months shelf life on all ingredients; supported by extensive stability data on ingredients and finished formulations.
Approvals: Novel Food (EU), TGA (AUS), GRAS (USA), drug registration in India (2017). Application processes are initiated in countries including China, Thailand and others. Kosher and Halal certifications.

Kappa developed the K2 Formulation LookBook, including more than 120 ready-to-use product formulations and dosage forms targeted towards all K2 health applications and a wide range of consumer groups.

Kappa’s on-going ExperienceCard Program develops innovative vitamin K2 formulations in collaboration with industry leaders. Each ExperienceCard concept represents a novel product formulation that is specifically designed to solve an existing market problem or to address a health segment or consumer group in a new way. K2VITAL® vitamin K2 MK-7 provides the central ingredient in each of the products. Partners provided synergistic co-ingredients, innovative dosage or manufacturing technology, or other elements that make these forward-looking products possible.

K2 Introduction

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The History of K2

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The Different Vitamins in the K Family

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All-trans Means All-bioactive

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K2 Deficiency

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